Arginine deiminase system and acid adaptation of oral streptococci

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Arginine deiminase system and acid adaptation of oral streptococci.

Streptococcus rattus FA-1 and Streptococcus sanguis NCTC 10904 underwent phenotypic acid adaptation in batch cultures toward the end of sugar-fueled growth after the culture pH had dropped to triggering values. The bacteria could be derepressed or induced for arginine deiminase independently of acid adaptation, and arginolysis afforded protection against acid killing over and above that of acid...

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Arginine deiminase system and bacterial adaptation to acid environments.

The arginine deiminase system in a variety of streptococci and in Pseudomonas aeruginosa was found to be unusually acid tolerant in that arginolysis occurred at pH values well below the minima for growth and glycolysis. The acid tolerance of the system allowed bacteria to survive potentially lethal acidification through production of ammonia to raise the environmental pH value.

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Arginine Deiminase from Mycoplasma arthritidis

Hydrodynamic, chemical, and optical properties of arginine deiminase (EC 3.5.3.6) from Mycoplasma arthritidis are reported for the enzyme isolated from log phase cells. The s& +, and D’& values of the enzyme are 5.48 S and 5.87 x 10V7 cm’/s, respectively; the molecular weight is 87,300. Determination of the amino acid composition shows that about 45% of the residues are nonpolar. Another unique...

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Evolution of arginine deiminase (ADI) pathway genes.

We have analyzed the evolution of the three genes encoding structural enzymes of the arginine deiminase (ADI) pathway, arginine deiminase (ADI), ornithine transcarbamoylase (OTC), and carbamate kinase (CK) in a wide range of organisms, including Archaea, Bacteria, and Eukarya. This catabolic route was probably present in the last common ancestor to all the domains of life. The results obtained ...

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Metabolic Reprogramming in Arginine Deiminase-Resistant Cells

Authors’ Affiliations: Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, Sylvester Comprehensive Cancer Center, University of Miami, Miami, Florida; Department of Neurology and Brain Science Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland *These authors contributed equally Corresponding Author: Macus T...

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ژورنال

عنوان ژورنال: Applied and Environmental Microbiology

سال: 1995

ISSN: 0099-2240,1098-5336

DOI: 10.1128/aem.61.12.4494-4496.1995